Casein Kinase-1 Phosphorylates the p75 Tumor Necrosis Factor Receptor and Negatively Regulates Tumor Necrosis Factor Signaling for Apoptosis
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چکیده
منابع مشابه
Tumor necrosis factor receptor-mediated signaling pathways
T UMOR necrosis factor c~ (TNF) ~ and tumor necrosis factor ~ (lymphotoxin) are two cytokines produced primarily by macrophages and lymphocytes, respectively. These cytokines are recognized by the same cell surface receptors and are associated with similar biological activities. Some of the well-known TNF effects include septic shock, cytotoxicity, inflammation, and cachexia. The role of TNF in...
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Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.40.23293